Mt. Kenya, Kenya – 1982

There is something very special leaving UK in January and travelling to the equator. Twenty members thoroughly enjoyed the Kenyan highland experience and in the game parks afterwards.

On the mountain we saw colobus and sykes monkeys and, after traversing the vertical bog, hyrax, lobelias, and senecios. Our research projects included a comparison of acetazolamide and a more potent, lipophilic, carbonic anhydrase inhibitor, methazolamide for the prevention of acute mountain sickness (AMS) during a trek to the hut at 4790m just below Point Lenana (4985m). AMS was prevented equally well, blood gases were not different and side effects were similar. At 3600m methazolaminde showed a more rapid rise in PaO2 on acute therapy.

The Times summed up the depressed feeling in the UK at the time and the results of our expedition with a brilliant cartoon by Calman. Albuminuria studies and plasma lactate measurements were included and AMS scoring was compared using interviews, peer review and self-completed questionnaires.

Publications:

  1. Bradwell AR, Coles B, Fletcher RF and Wright AD. Comparison of acetazolamide and methazolamide in acute mountain sickness. Clinical Science 1982; 63(3): 74. DOI: 10.1042/cs063074Pa
  2. Fletcher R. Acute Mountain Sickness Revisited. Aesculapius 1982; (2): 36-37.
  3. Forster PJG. Methazolamide in acute mountain sickness. Lancet 1982; 319: 1254. https://doi.org/10.1016/S0140-6736(82)92385-6
  4. Miller MR, Pincock AC and Wright AD. Predicting susceptibility to acute mountain sickness. Lancet 1983; 321: 164.
  5. Wright AD, Bradwell AR and Fletcher MD. Methazolamide and acetazolamide in acute mountain sickness. Aviation, Space and Environmental Medicine. 1983; 54(7): 619-621.
  6. Wright AD, Bradwell AR, Fletcher RF, Green ID, Harvey TC, Milles JJ and BMRES. Methazolamide and acetazolamide in acute mountain sickness. Hypoxia, Exercise and Altitude: Proceedings of the 3rd International Hypoxia Symposium 1983. Progress in Clinical and Biological Research 1983; 136: 483. Ed JR Sutton and others; Alan R Liss, Inc, New York.
  7. Wright AD, Black EG, Fletcher RF, Bradwell AR and BMRES. Thyroid function at high altitude. New England Journal of Medicine 1984; 310: 1334. DOI: 10.1056/NEJM198405173102022
  8. Bradwell AR. Exercise in Futility. Aesculapius 1984; (4): 22-26.
  9. Forster P. Reproducibility of individual response to exposure to altitude. British Medical Journal 1984; (289): 1269. 
  10. Mackintosh JH, Thomas DJ, Olive JE, Chesner IM, Knight RJE and BMRES. The effect of altitude on tests of reaction time and alertness. Aviation, Space and Environmental Medicine 1988; 59: 246-248.
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