Karakoram, Pakistan – 1987

The interesting journey via Islamabad and Skardu with views of Nanga Parbat, mighty rivers, apricots drying, mulberries dropping off the trees and walnuts ripening, ended in a meadow of orchids for our baseline experiments in the village of Hushe, The area of mountains was west of the disputed Siachen glacier on the border of Pakistan and India.

A region of great peaks – Masherbrum (K1 7821m), K7 (6934m) and Laila peak 6096m) – and of glaciers (Gondoro and Godwin-Austen). The two main experiments were measurement of cerebral blood flow (collaborating with Prof Marcus Raichle) and sleep studies with the sedative, temazepam (collaborating with Dr Nicholson, RAF Farnborough).Other research projects included muscle strength measurements, visual evoked responses, effects of rebreathing CO2, dietary carbohydrate supplementation (Maxijul), capillary permeability and further studies on acetazolamide.

Expedition Team Members

  • Jo Bradwell – leader
  • Alex Wright – deputy leader
  • Peter Dykes – medical officer
  • John Simmons – quartermaster
  • R Boyce, I Chesner, J Coote, J Delamere, N Dorricott, J Evans, P Forster, Ginette Harrison, T Harvey, J Jensen, J Milles, J Potakar, M Raichle, N Richardson, D Siviter, P Smith (RAF), N Stanley (RAF) Barbara Stone (RAF), G Tsang, M Winterborn.

Expedition Highlights

  • Cricket match BMRES X1 vs. Skardu Police X1 ( Home team victory)
  • Porters dancing in camp to accompaniment of drums and hurrahs.
  • Group ascent of Gondoro Peak (18600 ft)
  • Porters singing as ascended snowfield to top camp (17800 ft) to
  • retrieve equipment on completion of research work
  • Descent on skis from top camp (ARB, NR, JM)
  • Trek out from Hushe to Skardu along Indus valley including crossing of river on raft made of inner tubes and inflated goat skins (dzak)
  • Bus journey from Skardu via Gilgit to Islamabad along Karakoram Highway

Publications:

  1. Bradwell AR, Winterborn MH, Wright AD, Forster PJG and Dykes PW. Acetazolamide treatment of acute mountain sickness. Clinical Science 1988; 74(s18): 62. DOI: 10.1042/cs074062Pb 
  2. Forster PJG. Microvascular fragility at high altitude. British Medical Journal 1988; (296): 1004-5.
  3. Harvey TC, Richardson NV, Winterborn MH, Jensen JB, Harrison GL and Bradwell AR. Carbon dioxide responses in subjects suffering from acute mountain sickness. Clinical Science 1988; 74(s18): 33. DOI: 10.1042/cs074033Pc
  4. Harvey TC, Winterborn MH, Lassen NA, Raichle ME, Jensen JB, Richardson NV and Bradwell AR. Effect of carbon dioxide in acute mountain sickness: A rediscovery. Lancet 1988; 8612(332): 639-641. 
  5. Wright AD, Bradwell AR, Jensen J and Lassen N. Cerebral blood flow in acute mountain sickness and treatment with acetazolamide. Clinical Science 1988; 74(s18): 1. DOI: 10.1042/cs074001P
  6. Bradwell AR, Harvey TC, Winterborn M, Wright AD, Forster PE, Dykes PW, Delamere J and BMRES. Acetazolamide  treatment of acute mountain sickness. The Sixth International Hypoxia Symposium 1989. Published in: Hypoxia. The Adaptations. Eds. JR Sutton, G Coates, JE Remmers. 1990; 292: A67. Publishers: BC Decker Inc.
  7. Chesner IM, Dykes PW, Lawson N and Bradwell AR. Assessment of small bowel absorption at altitude using D-xylose. The Sixth International Hypoxia Symposium 1989. Published in: Hypoxia. The Adaptations. Eds. JR Sutton, G Coates, JE Remmers. 1990; 297: A89. Publishers: BC Decker Inc.
  8. Dykes PW, Bushby J, Coote JH, Forster PH, Milles JJ, Richardson NV, Bradwell AR and BMRES. Loss of muscle bulk and strength at altitude. The Sixth International Hypoxia Symposium 1989. Published in: Hypoxia. The Adaptations. Eds. JR Sutton, G Coates, JE Remmers. 1990; 293: A74. Publishers: BC Decker Inc.
  9. Harrison GL, Evans J and Coote J. Discontinuation of acetazolamide after rapid ascent to 4300m. The Sixth International Hypoxia Symposium 1989. Published in: Hypoxia. The Adaptations. Eds. JR Sutton, G Coates, JE Remmers. 1990; 291: A63. Publishers: BC Decker Inc.
  10. Jensen JB, Wright AD, Lassen NA, Raichle ME and Bradwell AR. Cerebral blood flow at altitude. The Sixth International Hypoxia Symposium 1989. Published in: Hypoxia. The Adaptations. Eds. JR Sutton, G Coates, JE Remmers. 1990; 296: A83. Publishers: BC Decker Inc.
  11. Winterborn MH, Bradwell AR and BMRES. Mechanism of high altitude proteinuria. The Sixth International Hypoxia Symposium 1989. Published in: Hypoxia. The Adaptations. Eds. JR Sutton, G Coates, JE Remmers. 1990; 297: A88. Publishers: BC Decker Inc.
  12. Dykes PW, Bushby J, Coote JH, Forster PJG, Milles JJ, Bradwell AR and BMRES. Loss of muscle bulk and muscle force at altitude. Clinical Science 1990; 78(s22): 40. DOI: 10.1042/cs078040Pb 
  13. Jensen JB, Wright AD, Lassen NA, Harvey TC, Winterborn MH, Raichle ME and Bradwell AR. Cerebral blood flow in acute mountain sickness. Journal of Applied Physiology 1990; 69: 430-433. 
  14. Miller MR, Madan I, Wright JG, Lloyd JK, Milles JJ, and Pincock AC. The time course of change in hypercapnic ventilatory response after starting acetazolamide therapy. American Review of Respiratory Disease 1990; 141 (4:2): A304. 
  15. Winterborn MH, Bradwell AR and BMRES. Mechanisms of high altitude proteinuria. Clinical Science 1990; 78(s22): 19-20. Mechanisms of high altitude proteinuria. Clinical Science 1990; 78(s22): 19-20.
%d bloggers like this: