Chimborazo, Ecuador – 2016

On January 16th 2016, BMRES took 24 subjects to Ecuador. Our destination was the Whymper Hut at 5,000m above sea-level, last visited by the group in 1979- see the expedition archives for report and pictures. We performed further studies on exercise, sleep, and evaluation of pulmonary oedema by ultrasound. The subject group consisted of seasoned members as well as medical students, some of whom successfully climbed Chimborazo in difficult conditions.

Here are a selection of photos taken by expedition members, a full report is to follow.

Publications:

  1. Bradwell AR. Science and suffering at high altitude Chimborazo, Ecuador. January 2016. Aesculapius 2017. In press.
  2. Bradwell SB, Delamere J, Clarke A, Thomas O, Lewis C, Myers SD, Bradwell AR and Birmingham Medical Research Expeditionary Society. Effect of losartan on 24-hour and exercise albuminuria at 5000 m. BMRES Altitude Research conference Eds: Bradwell AR and Wright AD. 2016: p22.
  3. Clarke A, Ladha C, Baig F, Pattinson K and BMRES. Angiotensin II Receptor Blockade Attenuates High Altitude Sleep Disturbance. BMRES Altitude Research Conference Eds: Bradwell AR and Wright AD. 2016: p26.
  4. Delamere JP, Bradwell SB, Lewis C, Clarke A, Newman C, Shipman K and Birmingham Medical Expeditionary Society. Effect of losartan on 24-hour urine output, pH+ and electrolyte content during a trek to 5000 m. BMRES Altitude Research Conference Eds: Bradwell AR and Wright AD. 2016: p17.
  5. Gallagher C, Ashdown K, Lucas S, Ladha C, Wright A, Edsell M, Malein W, Thomas O, Bradwell A and Myers S. Losartan does not affect exercise performance at altitude (5000 m). BMRES Altitude Research Conference 2016 Eds: Bradwell AR and Wright AD. 2016: p18.
  6. Gault LE, Lewis CT, Lock HE and the Birmingham Medical Research Expeditionary Society (BMRES). Proceeding of the BMRES Altitude medicine conference: November 26th2016, Birmingham, United Kingdom. High altitude medicine and biology2017. Brief report; DOI: 10.1089/ham.2016.0146.
  7. Heymann M, Clarke A, Wright A, BMRES. Angotensin II Receptor Blockade has No Effect on High Altitude Symptomology. BMRES Altitude Research Conference Eds: Bradwell AR and Wright AD. 2016: p20.
  8. Imray CHE, Lock HE and Thomas O. Evaluation of Cognitive Function at Altitude Using the King-Devick Test. BMRES Altitude Research Conference Eds: Bradwell AR and Wright AD. 2016: p11.
  9. Imray CHE and Lock H. Chimborazo: Journey from the Centre of the Earth. The Adventure Medic. March 2016. http://www.theadventuremedic.com/adventures/bmres-chimborazojourney-from-the-centre-of-the-earth/
  10. Lewis CT, Newman C, Clarke S. Blood gas measurement at 5000m: is the Abbott i-Stat feasible? BMRES Altitude Research Conference Eds: Bradwell AR and Wright AD. 2016: p9.
  11. Lucas S, Newman C, Cadigan P, Johnson B, Wright A, Edsell M, Ashdown K, Gallagher C, Myers S, Bradwell AR. Effect of losartan on blood pressure during rest and exercise at 5000 m. BMRES Altitude Research Conference Eds: Bradwell AR and Wright AD. 2016: p25.
  12. Malein WL, Thomas O and Edsell M. Exercise Induces Pulmonary Interstitial Fluid at 5000 m in Healthy Individuals and Losartan Does Not Prove to be Protective. BMRES Altitude Research Conference Eds: Bradwell AR and Wright AD. 2016: p7. 
  13. Myers SD, Lucas S, Ashdown K, Malein W, Thomas O, Edsell M, Ladha C, Bradwell AR, Wright A and Gallagher C. Losartan does not affect maximal exercise performance at high altitude 5000 m. Medicine and Science in Sports and Exercise 2017; (49): s5. 
  14. Newman C, Lewis CT, Gallagher C and Clarke S. Losartan and its effects on capillary blood gas and response to Acetazolamide at altitude. BMRES Altitude Research Conference Eds: Bradwell AR and Wright AD. 2016: p8.
  15. Carke A, Cozzi M, Hand C, Imray C, Pagliarini S. The Impact of Imaging Modalities and Acetazolamide on Retinal Vessel Diameter at High Altitude. Investigative Ophthalmology and Visual Science 2017; 58(8): 4824.
  16. Cozzi M, Clarke A, Imray C and Pagliarini S. Optical Coherence Tomography retinal segmentation changes induced by gradual ascent to high altitude in mountaineers randomized to acetazolamide vs placebo. Investigative Ophthalmology and Visual Science 2017; 58(8): 4823.
  17. Myers SD, Lucas S, Ashdown K, Malein W, Thomas O, Edsell, M, Ladha C, Bradwell AR, Wright A and Gallagher C. Losartan does not affect maximal exercise performance at high altitude 5000 m. Medicine and Science in Sports and Exercise 2017; (49): s5.
  18. Sagoo RS, Hutchinson C, Wright A, Handford C, Parsons H, Sherwood V, Wayte S, Nagaraja S, Ng’Andwe E, Wilson M, Imray CHE for the BMRES.  Magnetic Resonance investigation into the mechanisms involved in the development of high-altitude cerebral edema. Journal Cerebral Blood Flow Metabolism 2017; 37(1): 319-331 doi:10.1177/0271678X15625350
  19. Bradwell AR, Ashdown K, Gallagher C, Delamere JP, Thomas OD, Lucas SJE, Wright AD, Harris SJ, Myers SD and Birmingham Medical Research Expeditionary Society. Acetazolamide reduces exercise capacity following a five-day ascent to 4,559 m on Monte Rosa. BMJ Open Sport and Exercise Medicine 2018; 4:e000302. doi:10.1136/ bmjsem-2017-000302
  20. Delamere JP, Bradwell AR, Bradwell SB, Joyce K, Lewis C, Clarke A, Newman C, Shipman K and Birmingham Medical Research Expeditionary Society. Losartan has no effect on hypoxic diuretic response to altitude. High Altitude Medicine & Biology2018; 19(4): 0005
  21. Joyce KE, Lucas SJE, Bradwell S, Delamere J, Myers S, Thomas O, Fountain A and Bradwell AR. Hypoxia is not the mechanism for exercise-induced proteinuria. High Altitude Medicine & Biology2018; 19(4): 0006
  22. Joyce KE, Bradwell S, Delamere J, Lucas SJE, Myers S, Thomas O, Fountain A, Bradwell AR and Birmingham Medical Research Expeditionary Society. Exercise proteinuria at altitude is reduced by acetazolamide. Europhysiology Meeting September 2018; 191 PCA167.
  23. Joyce KE, Bradwell S, Delamere J, Lucas SJE, Myers S, Thomas O, Fountain A, Bradwell AR and Birmingham Medical Research Expeditionary Society. Urinary orosomucoid (alpha-1-acid glycoprotein) latex immunoassay is effective for the detection of increased proteinuria associated with altitude and sea-level exercise. Europhysiology Meeting September 2018; 191 PCA166.
  24. Joyce KE, Lucas SJE, Imray CHE, Balanos GM and Wright AD.  Advances in the available non-biological pharmacotherapy prevention and treatment of acute mountain sickness and high altitude cerebral and pulmonary oedema 2018.  Expert Opinion on pharmacotherapy. 
  25. Lewis CT, Malein WL, Chesner I, Clarke S and on behalf of the Birmingham Medical Research Expeditionary Society. High altitude arterialised capillary earlobe blood gas measurement using the Abbott i-STAT. Journal of the Royal Army Medical Corps 2018; 164: 335-337
  26. Talks BJ, Bradwell SB, Delamere J, Rayner W, Clarke A, Lewis CT, Thomas OD and Bradwell AR. Urinary Alpha-1-Acid Glycoprotein is a Sensitive Marker of Glomerular Protein Leakage at Altitude. High Altitude Medicine & Biology 2018; 19; 295-298.
  27. Talks BJ, Bradwell SB, Delamere J, Rayner W, Clarke A, Lewis CT, Thomas OD and Bradwell AR. Urinary Alpha-1-Acid Glycoprotein is a Sensitive Marker of Glomerular Protein Leakage at Altitude. Book of Abstracts of the 23rd Annual Congress of the European College of Sport Science. Eds: Murphy M, Boreham C, De Vito G and Tsolakidis, E. 2018: 353.

Typical evening meeting, this time at the Marco Cruz huts.

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