Ladakh, India – 2005

A most successful and enjoyable expedition to Ladakh was undertaken by 17 members.

Research was based at 3450m in Leh where observations were made on arrival and after acclimatisation. Repeat of the exercise protocol done in Bolivia was extended to include more careful baseline respiration records, the recovery phase of the exercise and an assessment of arterial-venous shunting.

Some problems were encountered in getting standard gas canisters delivered and once again we resorted to a generator to ensure reliable supply of electricity. Weighing scales could not be found and so an improvised spring balance was used. Other research included pupil reaction times and assessment of arterial stiffness.

After trekking in the Markha valley some repeat measurements were made to assess acclimatisation. A valiant attempt to climb Stok Kangri (6137m) was thwarted by the snow conditions near the summit.

Publications:

  1. Chan C, Rhodes H, Chesterman K, Collins P, Pattinson K, Imray C, Wright A and BMRES. Peripheral vascular response is delayed in acute acclimatization to hypobaric hypoxia. 15thInternational Hypoxia Symposium. High altitude Medicine and Biology 2006; 4: 323, 11. 
  2. Chan C, Rhodes H, Chesterman K, Collins P, Pattinson K, Imray C and Wright A. Arterial compliance and vascular tone in acute mountain sickness. 15th International Hypoxia Symposium. High altitude Medicine and Biology 2006; 4: 323-324, 12. 
  3. Pattinson KTS, Wright AD, Chan CW and Imray CHE. Exercise-induced right to left shunting in healthy humans at high altitude. 15th International Hypoxia Symposium. High altitude Medicine and Biology 2006; 4: 339-340, 57. 
  4. Pattinson KTS, Imray CHE, Myers SD, Chan CW, Wright AD, Biccard BM and BMRES. Effect of acclimatisation on the ventilatory threshold in humans at high altitude. A key to understanding substrate utilisation associated with acclimatisation at high altitude. 15th International Hypoxia Symposium. High altitude Medicine and Biology 2006; 4: 340, 58. 
  5. Wright, AD. Medicine at high altitude. Clinical Medicine 2006; 6: 604-8. DOI: 10.7861/clinmedicine.6-6-604
  6. Imray CH, Pattinson KT, Myers S, Chan CW, Hoar H, Brearey S, Collins P, Wright AD and Birmingham Medical Research Expeditionary Society. Intrapulmonary and intracardiac shunting with exercise at altitude. Wilderness and Environmental Medicine 2008; 19: 199-204. 
  7. Myers SD, Biccard BM, Chan C, Imray CHE, Wright AD, Pattinson KTS and Birmingham Medical Research Expeditionary Society. Delayed acclimatization of the ventilatory threshold in healthy trekkers. Wilderness and Environmental Medicine 2008; 19: 124-128. 
  8. Wilson MH, Edsell M, Imray C, Wright A and BMRES. Changes in pupil dynamics at high altitude – an observational study using a handheld pupillometer. High Altitude Medicine and Biology 2008; 9(4): 319-325. DOI: 10.1089/ham.2008.1026
  9. Wright AD, Breary SP and Imray, CHE. High hopes at high altitudes: pharmacotherapy for acute mountain sickness and high altitude cerebral and pulmonary oedema. Expert Opinion in  pharmacotherapy 2008; 9(1): 119-127. 
  10. Rhodes HL, Chesterman K, Chan CW, Collins P, Kewley E, Pattinson KTS, Myers S, Imray CHE, Wright AD and Birmingham Medical Research Expeditionary Society. Systemic blood pressure, arterial stiffness and pulse waveform analysis at altitude. Journal of the Royal Army Medical Corps 2011; 157(1): 110-113.
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