Rupina La, Nepal – 1984

Research:

  • Sleep studies in collaboration with John Coote and A Nicholson (RAF)
  • Acetazolamide and exercise
  • Changes in muscle mass
  • The effect of acetazolamide and altitude on red cell 2,3 diphosphoglycerate.

Members:

Jo Bradwell
Martin Bradwell
John Coote
Frank Davies
Nev Richardson
Ian Chesner
John Simmons
John Milles
Goronwy Jones
David Siviter
Simon Morrissey
Tim Harvey
Ginette Harrison
Peter Forster
John Taverner
Pete Smith
Jonathan Evans
Peter Dykes
Mike Winterborn

Happy memories from Tim Harvey…

We all set off from Kathmandu and then from near Gorka, proceeded over and along a ridge, (?Barpak) slaughtered a goat than a buffalo. Then Gron Martin (and I) went down to Baudha whilst the others proceeded down a deep gorge and then up to a camp on a glacier at Rupina La (3764m) where I caught up later. Ginette and yourself pioneered an ascent of Samru (5670m) and Jo, Simon, Siviter, myself and at least two others climbed it the following day. (?Davies ? Winterborn) Ginette was disabled with snow blindness and the generators wouldn’t work at altitude.

On returning down the valley – a very long way – we lost Chesner but later refound him two days later. I remember a row between Coote and yourself about responsibility. Peter Smith nearly ‘copped it’ during a smoking experiment!

Publications:

  1. Chesner IM, Milles JJ, Oldfield S, Bradwell AR and BMRES. Effects of acetazolamide on 2,3 diphosphoglycerate (DPG) levels at altitude. Clinical Science 1985; 69(s12): 75. DOI: 10.1042/cs069075Pa 
  2. Coote JH, Bradwell AR, Winterborn M, Chesner I and BMRES. Beneficial effect of Diamox on exercise at altitude. The Fifth International Hypoxia Symposium 1985. Eds. JR Sutton, G Coates, JE Remmers. Publishers: BC Decker Inc.1985; 52.
  3. Coote JH, Bradwell AR, Winterborn M, Chesner I and BMRES. The effects of acetazolamide on exercise at altitude. Clinical Science 1985; 69(s12): 74. DOI: 10.1042/cs069074Pa
  4. Dykes PW, Richardson NV, Milles J, Forster P, Coote JH, Bradwell AR and BMRES. Muscle, fat and body weight loss at altitude. Clinical Science 1985; 69(s12): 29. DOI: 10.1042/cs069029Pb
  5. Fletcher RF, Wright AD, Jones GT and Bradwell AR. The clinical assessment of acute mountain sickness. Quarterly Journal of Medicine 1985; 54(1): 91-100.
  6. Wright AD, Jones GT, Fletcher RF, Mackintosh JH and Bradwell AR. The Environmental Symptoms Questionnaire in acute mountain sickness. Aviation, Space and Environmental Medicine 1985; 56: 572-575.
  7. Bradwell AR, Coote JH, Nicholson AN, Smith PA and Stone BM. Altitude insomnia in man. Journal of Physiology 1986; 373: 43. 
  8. Bradwell AR, Dykes PW, Coote JH, Forster PJG, Milles JJ, Chesner I, Richardson NV. Effect of acetazolamide on exercise performances and muscle mass at high altitude. Lancet 1986; 8488(327): 1001-1005.
  9. Forster PJG, Nuki G, Rylance HJ, Wallace RC and BMRES. Effect of high altitude and Acetazolamide on human serum and urine purines. Published in: Purine and Pyrimidine Metabolism in Man V E. Eds.W.L Nyhan, LF Thompson and RWE Watts. 1986; 601-607. Publishers: Plemun Publishing Corporation.
  10. Forster P, Nuki G, Rylance HJ, Wallace RC and BMRES. Effects of high altitude and acetazolamide on human serum and urine purines. Clinical Science 1986; 70(s13): 87.DOI: 10.1042/cs070087Pa 
  11. Winterborn M, Bradwell AR, Chesner I, Jones G and BMRES. Mechanism of proteinuria at high altitude. Clinical Science 1986; 70(s13): 58. DOI: 10.1042/cs070058Pa
  12. Wright AD, Binns NB, Coote JH and Bradwell AR. Blood lactate concentrations and exercise at high altitude. Clinical Science 1986; 70(s13): 82. DOI: 10.1042/cs070082Pb 
  13. Binns N, Wright AD, Singh BM, Coote JH and Bradwell AR. Blood lactate changes during exercise at high altitude. Postgraduate Medical Journal 1987; 63(737): 177-178.
  14. BMRES (anonymous). Acetazolamide prophylaxis for acute mountain sickness. Drug and Therapeutics Bulletin 1987; 25(12): 45-47.
  15. Bradwell AR, Dykes PW and Coote JH. Effect of acetazolamide on exercise at altitude. Sports Medicine 1987; 4(3): 157-163. 
  16. Bradwell AR and Coote JH. The BMRES 1984 Medical Research Expedition to the Himalayas. Postgraduate Medical Journal 1987; 63: 165-167. 
  17. Chesner IM, Small NA and Dykes PW. Intestinal absorption at high altitude. Postgraduate Medical Journal 1987; 63(737): 173-175. 
  18. Coote JH, Bradwell AR, Winterborn MH and Chesner I. The effect of carbonic anhydrase inhibitors on exercise at high altitude. Postgraduate Medical Journal 1987; 63(737): 193. 
  19. Dykes PW, Binns N, Bradwell AR, Busby J and Forster PJG. Changes in body weight, fat and muscle mass at high altitude and the effect of acetazolamide. Postgraduate Medical Journal 1987; 63(737):192. 
  20. Milles JJ, Chesner IM, Oldfield S and Bradwell AR. Effect of acetazolamide on blood gases and 2,3 DPG during ascent and acclimatization to high altitude. Postgraduate Medical Journal 1987; 63(737): 183-184. 
  21. Morrissey SC, Keohane K, Coote JH. The effect of acetazolamide on breath holding at high altitude. Postgraduate Medical Journal 1987; 63(737): 189-190. 
  22. Nicholson AN, Smith PA, Stone BM, Bradwell AR and Coote JH. Effects of acetazolamide and temazepam on sleep at high altitude. Postgraduate Medical Journal 1987; 63(737): 191.  
  23. Winterborn MH, Bradwell AR, Chesner I and Jones GT. The origin of proteinuria at high altitude. Postgraduate Medical Journal 1987; 63(737): 179-181.  
  24. Wright AD and Fletcher RF. Acute mountain sickness. Postgraduate Medical Journal 1987; 63(737): 163-164. 
  25. Nicholson AN, Smith PA, Stone BM, Bradwell AR and Coote JH. Altitude insomnia: studies during an expedition to the Himalayas. Sleep 1988; 11: 354-361. 
%d bloggers like this: